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Johann Zimmermann Selected Research

NVP-AEW541

7/2008Inhibition of insulin-like growth factor-I receptor (IGF-IR) using NVP-AEW541, a small molecule kinase inhibitor, reduces orthotopic pancreatic cancer growth and angiogenesis.
5/2008The insulin-like growth factor-I receptor inhibitor NVP-AEW541 provokes cell cycle arrest and apoptosis in multiple myeloma cells.

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Johann Zimmermann Research Topics

Disease

10Neoplasms (Cancer)
02/2023 - 03/2004
5Breast Neoplasms (Breast Cancer)
02/2023 - 10/2007
4Prostatic Neoplasms (Prostate Cancer)
01/2023 - 03/2004
4Neoplasm Metastasis (Metastasis)
01/2023 - 10/2007
1Bone Resorption
08/2019
1Bronchiectasis
02/2019
1Cystic Fibrosis (Mucoviscidosis)
02/2019
1Triple Negative Breast Neoplasms
11/2015
1Bone Diseases (Bone Disease)
11/2015
1Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
10/2015
1Osteoporosis
07/2008
1Pancreatic Neoplasms (Pancreatic Cancer)
07/2008
1Multiple Myeloma
05/2008
1Osteolysis
10/2007

Drug/Important Bio-Agent (IBA)

3Docetaxel (Taxotere)FDA Link
02/2023 - 01/2023
3Proteins (Proteins, Gene)FDA Link
11/2015 - 03/2004
2Biomarkers (Surrogate Marker)IBA
02/2023 - 01/2023
2Therapeutic UsesIBA
02/2023 - 01/2023
2Trastuzumab (Herceptin)FDA Link
02/2023 - 01/2023
2plerixaforFDA Link
02/2023 - 01/2023
2balixafortideIBA
01/2023 - 06/2021
2eribulinFDA Link
06/2021 - 11/2015
2Cathepsin KIBA
08/2019 - 10/2007
2POL5551IBA
11/2015 - 10/2015
2NVP-AEW541IBA
07/2008 - 05/2008
2IGF Type 1 Receptor (IGF 1 Receptor)IBA
07/2008 - 05/2008
2isopeptidaseIBA
09/2006 - 03/2004
2Fatty Acid Synthases (Fatty Acid Synthase)IBA
09/2006 - 03/2004
1LuciferasesIBA
01/2023
1Conditioned Culture MediaIBA
08/2019
1Serine Proteases (Serine Protease)IBA
08/2019
1Cysteine Proteases (Cysteine Protease)IBA
08/2019
1Matrix Metalloproteinases (MMPs)IBA
08/2019
1Peptide Hydrolases (Proteases)FDA Link
08/2019
1Leukocyte Elastase (Neutrophil Elastase)IBA
02/2019
1farnesyl pyrophosphate (farnesyl diphosphate)IBA
11/2015
1EpitopesIBA
11/2015
1Diphosphonates (Bisphosphonates)IBA
11/2015
1MineralsIBA
11/2015
1CXCR4 Receptors (CXCR4 Receptor)IBA
11/2015
1Phosphotransferases (Kinase)IBA
07/2008
1Mevalonic Acid (Mevalonate)IBA
07/2008
1Insulin-Like Growth Factor I (IGF-1)IBA
07/2008
1CholesterolIBA
07/2008
1Zoledronic Acid (Zometa)FDA Link
10/2007
1Fatty Acids (Saturated Fatty Acids)IBA
09/2006
1Oncogene Proteins (Oncogene Protein)IBA
08/2005
1EnzymesIBA
08/2005
1AndrogensIBA
03/2004

Therapy/Procedure

6Therapeutics
02/2023 - 10/2007
1Drug Therapy (Chemotherapy)
11/2015